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Article

Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors.

The Journal of biological chemistry - 10 Dec 2010

Shimura Kazuya, Nameki Daisuke, Kajiwara Keiko, Watanabe Kentaro, Sakagami Yasuko, Oishi Shinya, Fujii Nobutaka, Matsuoka Masao, Sarafianos Stefan G, Kodama Eiichi N

Abstract excerpt

Human immunodeficiency virus (HIV) gp41 plays a key role in viral fusion; the N- and C-terminal heptad repeats (N-HR and C-HR) of gp41 form a stable 6-helical conformation for fusion. Therefore, HR-derived peptides, such as enfuvirtide (T-20), inhibit HIV-1 fusion by acting as decoys, and have be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20937812
DOI: 10.1074/jbc.M110.145789
PMCID: PMC2998136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20937812-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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