Article
Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens.
Cell chemical biology - 20 Oct 2016
Liu Xueping, Baarsma Hoeke Abele, Thiam Chung Hwee, Montrone Corinna, Brauner Barbara, Fobo Gisela, Heier Julia-Sophie, Duscha Sven, Königshoff Melanie, Angeli Veronique, Ruepp Andreas, Campillos Monica
Abstract excerpt
Phenotypic drug discovery offers some advantages over target-based methods, mainly because it allows drug leads to be tested in systems that more closely model distinct disease states. However, a potential disadvantage is the difficulty of linking the observed phenotype to a specific cellular target. To address this problem, we developed DePick, a computational target de-convolution tool to determine targets...
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