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Article

VNTR diversity in Yersinia pestis isolates from an animal challenge study reveals the potential for in vitro mutations during laboratory cultivation.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2016

Vogler Amy J, Nottingham Roxanne, Busch Joseph D, Sahl Jason W, Shuey Megan M, Foster Jeffrey T, Schupp James M, Smith Susan R, Rocke Tonie E, Keim Paul, Wagner David M

Abstract excerpt

Underlying mutation rates and other evolutionary forces shape the population structure of bacteria in nature. Although easily overlooked, similar forces are at work in the laboratory and may influence observed mutations. Here, we investigated tissue samples and Yersinia pestis isolates from a rodent laboratory challenge with strain CO92 using whole genome sequencing and multi-locus variable-number tandem repeat...

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PMID: 27664903
DOI: 10.1016/j.meegid.2016.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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