Article

DMD Human iPSC-derived skeletal muscle cells recapitulate selective calcium dysregulation pathways

2024-01-20

Abstract excerpt

<h4>Summary</h4> This study investigates the functional characteristics of induced pluripotent stem cell-derived muscle cells (hiPSC-skMCs) from Duchenne muscular dystrophy (DMD) patients, focusing on their regulation of intracellular calcium concentration. DMD, a progressive muscle degenerative disease, arises from mutations in the dystrophin gene and is characterized by elevated intracellular calcium levels, ex...

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Literature Corpus work: 55c224eb-6712-5b18-9b78-e760793d8199
DOI: 10.1101/2024.01.20.576393

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