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Article

Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene.

Nucleic acid therapeutics - 1 Dec 2016

Kralovicova Jana, Moreno Pedro M D, Cross Nicholas C P, Pêgo Ana Paula, Vorechovsky Igor

Abstract excerpt

ATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. ATM mutations in the germ line result in ataxia-telangiectasia (A-T), a rare genetic syndrome associated with hypersensitivity to double-strand DNA breaks and predisposition to lymphoid malignancies. ATM expression is limited by a tightly regulated nonsense-mediated...

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Identifiers

PMID: 27658045
DOI: 10.1089/nat.2016.0635
PMCID: PMC5105335

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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