Article
Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory.
The European journal of neuroscience - 1 Jun 2005
Ris L, Angelo M, Plattner F, Capron B, Errington M L, Bliss T V P, Godaux E, Giese K P
Abstract excerpt
p25, a degradation product of p35, has been reported to accumulate in the forebrain of patients with Alzheimer's disease. p25 as well as p35 are activators of cyclin-dependent kinase 5 (Cdk5) although p25/Cdk5 and p35/Cdk5 complexes have distinct properties. Several mouse models with high levels of p25 expression exhibit signs of neurodegeneration. On the contrary, we have shown that low levels of p25 expression...
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