Article
Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.
G3 (Bethesda, Md.) - 2 Feb 2018
Maurizio Paul L, Ferris Martin T, Keele Gregory R, Miller Darla R, Shaw Ginger D, Whitmore Alan C, West Ande, Morrison Clayton R, Noll Kelsey E, Plante Kenneth S, Cockrell Adam S, Threadgill David W, Pardo-Manuel de Villena Fernando, Baric Ralph S, Heise Mark T, Valdar William
Abstract excerpt
Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic architecture is not well understood. Here, we obtain a broad view of how heritable factors affect a mouse model of response to IAV infection using an 8 × 8 diallel of the eight...
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