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Article

Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene.

Epigenetics - 1 Dec 2022

Poppova Lucie, Pavlova Sarka, Gonzalez Beatriz, Kotaskova Jana, Plevova Karla, Dumbovic Gabrijela, Janovska Pavlina, Bystry Vojtech, Panovska Anna, Bezdekova Lucie, Maslejova Stanislava, Brychtova Yvona, Doubek Michael, Krzyzankova Marcela, Borsky Marek, Mayer Jiri, Bryja Vitezslav, Alonso Sergio, Pospisilova Sarka

Abstract excerpt

Genome methylation profiles define naïve-like (n-CLL), memory-like (m-CLL), and intermediate (i-CLL) subsets of chronic lymphocytic leukaemia (CLL). The profiles can be easily determined by the analysis of the five-CpG signature. m-CLL, i-CLL, and n-CLL with the good, intermediate, and poor prognoses, respectively, differ by the somatic hypermutation status of the immunoglobulin heavy chain variable gene (IGHV),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 35333703
DOI: 10.1080/15592294.2022.2050004
PMCID: PMC9621079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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