Article
High expression of lymphocyte-activation gene 3 (LAG3) in chronic lymphocytic leukemia cells is associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and reduced treatment-free survival.
The Journal of molecular diagnostics : JMD - 1 May 2010
Kotaskova Jana, Tichy Boris, Trbusek Martin, Francova Hana Skuhrova, Kabathova Jitka, Malcikova Jitka, Doubek Michael, Brychtova Yvona, Mayer Jiri, Pospisilova Sarka
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is characterized by a monoclonal expansion of mature B-lymphocytes. Mutational status of the immunoglobulin variable heavy chain region (IGHV) gene stratifies CLL patients into two prognostic groups. We performed microarray analysis of CLL cells using the Agilen...
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