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Article

The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers.

Scientific reports - 19 Sept 2016

Alshareef Abdulraheem, Zhang Hai-Feng, Huang Yung-Hsing, Wu Chengsheng, Zhang Jing Dong, Wang Peng, El-Sehemy Ahmed, Fares Mohamed, Lai Raymond

Abstract excerpt

Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK(+) tumours, clinical resistance to this drug has been well recognized and the mechanism of this phenomenon is incompletely understood. Using the cellular thermal shift assay (CETSA), we measured the Crizotinib-ALK...

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Identifiers

PMID: 27641368
DOI: 10.1038/srep33710
PMCID: PMC5027386

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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