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Article

Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay

3 Jan 2018

Abstract excerpt

Androgen Receptor (AR) is a key driver in prostate cancer. Direct targeting of AR has valuable therapeutic potential. However, the lack of disease relevant cellular methodologies capable of discriminating between inhibitors that directly bind AR and those that instead act on AR co-regulators has made identification of novel antagonists challenging. The Cellular Thermal Shift Assay (CETSA) is a technology enabling...

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PMID: 29317749
DOI: 10.1038/s41598-017-18650-x

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