Article
Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit.
Critical reviews in biochemistry and molecular biology - 1 Aug 2011
DiNitto Jonathan P, Wu Joe C
Abstract excerpt
The inhibition of protein kinases has gained general acceptance as an effective approach to treat a wide range of cancers. However, in many cases, prolonged administration of kinase inhibitors often leads to acquired resistance, and the therapeutic effect is subsequently diminished. The wealth of recent studies using biochemical, kinetic, and structural approaches have revealed the molecular basis for the...
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