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Targeting Anaplastic Lymphoma Kinase in Lung Cancer

2 Feb 2011

Abstract excerpt

Several decades of cancer research have revealed a pivotal role for tyrosine kinases as key regulators of signaling pathways, controlling cell growth and differentiation. Deregulation of tyrosine kinase-mediated signaling occurs frequently in cancer and is believed to drive the initiation and progression of disease. Chromosomal rearrangements involving the tyrosine kinase anaplastic lymphoma kinase (ALK) occur in...

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PMID: 21288922
DOI: 10.1158/1078-0432.ccr-10-1591

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