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Article

What determines the switch between atrophic and neovascular forms ofage related macular degeneration? - the role of BMP4 induced senescence

12 Aug 2009

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, targets the retinal pigment epithelium (RPE), a monolayer of cells at the back of the eye. As AMD progresses, it can develop into two distinct forms of late AMD: "dry," atrophic AMD, characterized by RPE senescence and geographic RPE loss, and "wet," neovascular AMD, characterized by RPE activation with abnormal growth of...

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PMID: 20157553
DOI: 10.18632/aging.100078

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