Article
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016
Darash-Yahana Merav, Pozniak Yair, Lu Mingyang, Sohn Yang-Sung, Karmi Ola, Tamir Sagi, Bai Fang, Song Luhua, Jennings Patricia A, Pikarsky Eli, Geiger Tamar, Onuchic José N, Mittler Ron, Nechushtai Rachel
Abstract excerpt
Iron-sulfur (Fe-S) proteins are thought to play an important role in cancer cells mediating redox reactions, DNA replication, and telomere maintenance. Nutrient-deprivation autophagy factor-1 (NAF-1) is a 2Fe-2S protein associated with the progression of multiple cancer types. It is unique among Fe-S proteins because of its 3Cys-1His cluster coordination structure that allows it to be relatively stable, as well...
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