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Enterovirus A71 DNA-Launched Infectious Clone as a Robust Reverse Genetic Tool

12 Sept 2016

Abstract excerpt

Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot and mouth disease, and is occasionally associated with neurological complications and death in children. Reverse genetics is widely used in the field of virology for functional study of viral genes. For EV-A71, such tools are limited to clones that are transcriptionally controlled by T7/SP6 bacteriophage promoter. This is often time-consuming and...

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PMID: 27617744
DOI: 10.1371/journal.pone.0162771

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