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Article

Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.

International journal of cancer - 1 Jan 2017

Kraus Cornelia, Hoyer Juliane, Vasileiou Georgia, Wunderle Marius, Lux Michael P, Fasching Peter A, Krumbiegel Mandy, Uebe Steffen, Reuter Miriam, Beckmann Matthias W, Reis André

Abstract excerpt

Breast and ovarian cancer (BC/OC) predisposition has been attributed to a number of high- and moderate to low-penetrance susceptibility genes. With the advent of next generation sequencing (NGS) simultaneous testing of these genes has become feasible. In this monocentric study, we report results of panel-based screening of 14 BC/OC susceptibility genes (BRCA1, BRCA2, RAD51C, RAD51D, CHEK2, PALB2, ATM, NBN, CDH1,...

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Source

Identifiers

PMID: 27616075
DOI: 10.1002/ijc.30428

Genes

BRCA1
BRCA2
PALB2
ATM
CDH1
CHEK2
MLH1
MSH2
MSH6
NBN
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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