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Article

Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender.

Biochemical pharmacology - 1 Nov 2016

Shi Jian, Wang Xinwen, Nguyen Jenny-Hoa, Bleske Barry E, Liang Yan, Liu Li, Zhu Hao-Jie

Abstract excerpt

The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated with lower DAB plasma concentrations in the Randomized...

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Source

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Identifiers

PMID: 27614009
DOI: 10.1016/j.bcp.2016.09.003
PMCID: PMC5061634

Genes

CES1
CES2

Variants

rs71647871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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