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Geroconversion: irreversible step to cellular senescence

11 Nov 2014

Abstract excerpt

Cellular senescence happens in 2 steps: cell cycle arrest followed, or sometimes preceded, by gerogenic conversion (geroconversion). Geroconvesrion is a form of growth, a futile growth during cell cycle arrest. It converts reversible arrest to irreversible senescence. Geroconversion is driven by growth-promoting, mitogen-/nutrient-sensing pathways such as mTOR. Geroconversion leads to hyper-secretory,...

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PMID: 25483060
DOI: 10.4161/15384101.2014.985507

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