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Article

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.

Oncotarget - 1 Dec 2012

Berman Albert E, Leontieva Olga V, Natarajan Venkatesh, McCubrey James A, Demidenko Zoya N, Nikiforov Mikhail A

Abstract excerpt

It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm is being replaced by the "hyperfunction theory", which postulates that aging is caused by activation of signal transduction pathways such as TOR (Target of Rapamycin). These pathways consist...

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Identifiers

PMID: 23455653
DOI: 10.18632/oncotarget.889
PMCID: PMC3681491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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