Article
LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).
Proteomics - 1 Feb 2016
Poulsen Ebbe Toftgaard, Nielsen Nadia Sukusu, Jensen Morten M, Nielsen Esben, Hjortdal Jesper, Kim Eung Kweon, Enghild Jan J
Abstract excerpt
More than 60 mutations in transforming growth factor beta-induced protein (TGFBIp) have been reported in humans causing a variety of phenotypic protein aggregates in the cornea, commonly termed corneal dystrophies. One mutation, generating an arginine to histidine amino acid substitution at position 124 in mature TGFBIp leads to granular corneal dystrophy type 2 (GCD2). Homozygous GCD2 cases develop massive...
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