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Article

Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.

Biophysical journal - 6 Sept 2016

Okuda Masahiko, Higo Junichi, Komatsu Tadashi, Konuma Tsuyoshi, Sugase Kenji, Nishimura Yoshifumi

Abstract excerpt

General transcription factor II E (TFIIE) contains an acid-rich region (residues 378-393) in its α-subunit, comprising 13 acidic and two hydrophobic (Phe387 and Val390) residues. Upon binding to the p62 subunit of TFIIH, the acidic region adopts an extended string-like structure on the basic groove of the pleckstrin homology domain (PHD) of p62, and inserts Phe387 and Val390 into two shallow pockets in the...

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Source

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Identifiers

PMID: 27602723
DOI: 10.1016/j.bpj.2016.07.042
PMCID: PMC5018150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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