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Article

Extended string binding mode of the phosphorylated transactivation domain of tumor suppressor p53.

Journal of the American Chemical Society - 8 Oct 2014

Okuda Masahiko, Nishimura Yoshifumi

Abstract excerpt

The transactivation domain (TAD) of tumor suppressor p53 has homologous subdomains, TAD1 and TAD2. Both are intrinsically disordered in their free states, but all structures of TAD1 and TAD2 bound to their target proteins have demonstrated use of an amphipathic α-helix, suggesting that the binding-coupled helix folding mechanism of TAD1 and TAD2 is essential. Although phosphorylation of TAD is important to switch...

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Identifiers

PMID: 25216154
DOI: 10.1021/ja506351f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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