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Article

DNA methylation: conducting the orchestra from exposure to phenotype?

Clinical epigenetics - 1 Jan 2016

Leenen Fleur A D, Muller Claude P, Turner Jonathan D

Abstract excerpt

DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC), is considered to be one of the principal interfaces between the genome and our environment, and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27602172
DOI: 10.1186/s13148-016-0256-8
PMCID: PMC5012062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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