Article
Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Abdolmaleky Hamid Mostafavi, Smith Cassandra L, Faraone Stephen V, Shafa Rahim, Stone William, Glatt Stephen J, Tsuang Ming T
Abstract excerpt
Fine-tuning of neuronal connections during development is regulated through environmental interactions. Some fine-tuning occurs through changes in gene expression and/or epigenetic gene-specific DNA methylation states. DNA methylation occurs by transfer of a methyl group from S-adenosyl methionine to cytosine residues in the dinucleotide sequence CpG. Although CpG sequences spread throughout the genome are...
Topics
- CpG Islands
- DNA Methylation
- Environment
- Gene Expression Regulation
- Humans
- Mental Disorders
- Mutation
- Psychiatry
- Reelin Protein