Article
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.
mBio - 6 Sept 2016
Morisaki J Hiroshi, Smith Peter A, Date Shailesh V, Kajihara Kimberly K, Truong Chau Linda, Modrusan Zora, Yan Donghong, Kang Jing, Xu Min, Shah Ishita M, Mintzer Robert, Kofoed Eric M, Cheung Tommy K, Arnott David, Koehler Michael F T, Heise Christopher E, Brown Eric J, Tan Man-Wah, Hazenbos Wouter L W
Abstract excerpt
UNLABELLED: The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical S. aureus strains (MIC of ~1 µg/ml). The predominant clinical strain USA300 developed spontaneous resistance to...
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