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Article

Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia.

Cancer chemotherapy and pharmacology - 1 Nov 2016

Nielsen Stine Nygaard, Grell Kathrine, Nersting Jacob, Frandsen Thomas Leth, Hjalgrim Lisa Lyngsie, Schmiegelow Kjeld

Abstract excerpt

PURPOSE: Normal white blood cell counts (WBC) are unknown in children with acute lymphoblastic leukemia (ALL). Accordingly, 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy is adjusted by a common WBC target of 1.5-3.0 × 109/L. Consequently, the absolute degree of myelosuppression is unknown for the individual child and we wanted to evaluate this. METHODS: A median of 22 (range 8-27) 6MP/MTX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27600880
DOI: 10.1007/s00280-016-3151-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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