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Article

Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.

British journal of clinical pharmacology - 1 Dec 2008

Hawwa Ahmed F, Collier Paul S, Millership Jeff S, McCarthy Anthony, Dempsey Sid, Cairns Carole, McElnay James C

Abstract excerpt

AIMS: To investigate the population pharmacokinetics of 6-mercaptopurine (6-MP) active metabolites in paediatric patients with acute lymphoblastic leukaemia (ALL) and examine the effects of various genetic polymorphisms on the disposition of these metabolites. METHODS: Data were collected prospectively from 19 paediatric patients with ALL (n = 75 samples, 150 concentrations) who received 6-MP maintenance...

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Share to Antimetabolites, Antineoplastic
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mercaptopurine

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Share to Methyltransferases

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

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Identifiers

PMID: 18823306
DOI: 10.1111/j.1365-2125.2008.03281.x
PMCID: PMC2675766

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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