Article
Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors.
Molecular cancer therapeutics - 1 Dec 2016
Uitdehaag Joost C M, de Roos Jeroen A D M, Prinsen Martine B W, Willemsen-Seegers Nicole, de Vetter Judith R F, Dylus Jelle, van Doornmalen Antoon M, Kooijman Jeffrey, Sawa Masaaki, van Gerwen Suzanne J C, de Man Jos, Buijsman Rogier C, Zaman Guido J R
Abstract excerpt
Cancer cell line panels are important tools to characterize the in vitro activity of new investigational drugs. Here, we present the inhibition profiles of 122 anticancer agents in proliferation assays with 44 or 66 genetically characterized cancer cell lines from diverse tumor tissues (Oncolines). The library includes 29 cytotoxics, 68 kinase inhibitors, and 11 epigenetic modulators. For 38 compounds this is the...
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