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The DpnI/DpnII pneumococcal system, defense against foreign attack without compromising genetic exchange

8 Jul 2013

Abstract excerpt

Natural genetic transformation and restriction-modification (R–M) systems play potentially antagonistic roles in bacteria. R–M systems, degrading foreign DNA to protect the cell from bacteriophage, can interfere with transformation, which relies on foreign DNA to promote genetic diversity. Here we describe how the human pathogen Streptococcus pneumoniae, which is naturally transformable, yet possesses either of...

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PMID: 24195011
DOI: 10.4161/mge.25582

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