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Article

IL-7 suppresses osteogenic differentiation of periodontal ligament stem cells through inactivation of mitogen-activated protein kinase pathway.

Organogenesis - 1 Oct 2016

Jian Cong-Xiang, Fan Quan-Shui, Hu Yong-He, He Yong, Li Ming-Zhe, Zheng Wei-Yin, Ren Yu, Li Chen-Jun

Abstract excerpt

Periodontal ligament stem cells (PDLSCs) are tissue-specific mesenchymal stem cells (MSCs), having an important role in regenerative therapy for teeth loss. Interleukin-7 (IL-7) is a key cytokine produced by stromal cells including MSCs, and exhibits specific roles for B and T cell development and osteoblasts differentiation of multiple myeloma. However, the effect of IL-7 on osteogenic differentiation of PDLSCs...

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Source

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Identifiers

PMID: 27579861
DOI: 10.1080/15476278.2016.1229726
PMCID: PMC5198940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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