Lack of association between SREBF-1c gene polymorphisms and risk of non-alcoholic fatty liver disease in a Chinese Han population.

doi:10.1038/srep32110

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Lack of association between SREBF-1c gene polymorphisms and risk of non-alcoholic fatty liver disease in a Chinese Han population.

Scientific reports - 30 Aug 2016

Peng Xian-E, Chen Feng-Lin, Liu Wenjuan, Hu ZhiJian, Lin Xu

Abstract excerpt

The transcription factor sterol regulatory element-binding protein-1c (SREBP-1c) is a key regulator of lipogenesis and insulin sensitivity, and is associated with non-alcoholic fatty liver disease (NAFLD). Here, we assessed the impact of common single nucleotide polymorphisms (SNPs) in SREBF-1c on NAFLD susceptibility and associated metabolic phenotypes in a Han Chinese population. Four common SNPs (rs62064119,...

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PMID: 27572914
DOI: 10.1038/srep32110
PMCID: PMC5004200

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