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Article

Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.

EMBO reports - 7 Jan 2020

Trambauer Johannes, Rodríguez Sarmiento Rosa María, Fukumori Akio, Feederle Regina, Baumann Karlheinz, Steiner Harald

Abstract excerpt

Abnormal generation of neurotoxic amyloid-β peptide (Aβ) 42/43 species due to mutations in the catalytic presenilin 1 (PS1) subunit of γ-secretase is the major cause of familial Alzheimer's disease (FAD). Deeper mechanistic insight on the generation of Aβ43 is still lacking, and it is unclear whether γ-secretase modulators (GSMs) can reduce the levels of this Aβ species. By comparing several types of...

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Identifiers

PMID: 31762188
DOI: 10.15252/embr.201947996
PMCID: PMC6945062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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