Article
The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin.
Microbial pathogenesis - 1 Oct 2016
Mirza Shaper, Benjamin William H, Coan Patricia A, Hwang Shen-An, Winslett Anne-Kathryn, Yother Janet, Hollingshead Susan K, Fujihashi Kohtaro, Briles David E
Abstract excerpt
Pneumococcal surface protein A (PspA) is the only pneumococcal surface protein known to strongly bind lactoferrin on the bacterial surface. In the absence of PspA Streptococcus pneumoniae becomes more susceptible to killing by human apolactoferrin (apo-hLf), the iron-free form of lactoferrin. In the present study we examined diverse strains of S. pneumoniae that differed by 2 logs in their susceptibility to...
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