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Article

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

24 Apr 2018

Abstract excerpt

showed reduced mitochondrial degradation and retained thermogenic beige adipocytes even after the withdrawal of external stimuli. Norepinephrine signaling through the PKA pathway inhibited the recruitment of Parkin protein to mitochondria in beige adipocytes. However, mitochondrial proton uncoupling by uncoupling protein 1 (UCP1) was dispensable for Parkin recruitment and beige adipocyte maintenance. These...

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Share to Adipose Tissue and Metabolism
Share to Autophagy in Disease and Therapy
Share to Lipid metabolism and biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29692364
DOI: 10.1126/scisignal.aap8526

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