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Article

Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.

The Journal of investigative dermatology - 1 Jan 2017

Shams Kave, Wilson Gillian J, Singh Mark, van den Bogaard Ellen H, Le Brocq Michelle L, Holmes Susan, Schalkwijk Joost, Burden A David, McKimmie Clive S, Graham Gerard J

Abstract excerpt

Elucidating the poorly defined mechanisms by which inflammatory lesions are spatially restricted in vivo is of critical importance in understanding skin disease. Chemokines are the principal regulators of leukocyte migration and are essential in the initiation and maintenance of inflammation. The membrane-bound psoriasis-associated atypical chemokine receptor 2 (ACKR2) binds, internalizes and degrades most...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27568525
DOI: 10.1016/j.jid.2016.07.039
PMCID: PMC5176004

Genes

ACKR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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