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Article

Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma

7 Dec 2011

Abstract excerpt

Malignant pleural mesothelioma (MPM) usually develops pleural fluid. We investigated the value of DNA methylation in the pleural fluid for differentiating MPM from lung cancer (LC). Pleural fluid was collected from 39 patients with MPM, 46 with LC, 25 with benign asbestos pleurisy (BAP) and 30 with other causes. The methylation of O(6)-methylguanine-DNA methyltransferase (MGMT), p16(INK4a) , ras association...

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PMID: 22146010
DOI: 10.1111/j.1349-7006.2011.02180.x

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