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Article

FISH assay development for the detection of p16/CDKN2A deletion in malignant pleural mesothelioma

30 Jun 2010

Abstract excerpt

AIMS: To develop a fluorescence in-situ hybridisation (FISH) assay for detecting p16/CDKN2A deletion on paraffin tissue sections for use as an ancillary test to distinguish reactive from malignant mesothelial proliferations. METHOD: Dual-colour FISH for p16/CDKN2A and chromosome 9 (CEP-9) was performed on 11 benign mesothelial proliferations and 54 malignant pleural mesothelioma (MPM) cases to establish cut-off...

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PMID: 20591913
DOI: 10.1136/jcp.2010.076794

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