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Article

Adverse Effect of High-Fat Diet on Metabolic Programming in Offspring Born to a Murine Model of Maternal Hypertension.

American journal of hypertension - 1 Dec 2016

Longo Monica, Refuerzo Jerrie S, Mann Lovepreet, Leon Mateo, Moussa Hind N, Sibai Baha M, Blackwell Sean C

Abstract excerpt

BACKGROUND: We previously reported that offspring heterozygous mice partially lacking endothelial nitric oxide synthase (eNOS) gene, and born to hypertensive eNOS-/- Knockout mother, are hypertensive. We hypothesized that those offspring when placed on high-fat diet (HFD) will undergo altered metabolic programming increasing their risk for developing metabolic syndrome. METHODS: eNOS-/-KO and wild-type mice...

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Identifiers

PMID: 27565786
DOI: 10.1093/ajh/hpw088

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