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Article

Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner.

Epigenetics - 2 Jul 2016

Hocher Berthold, Haumann Hannah, Rahnenführer Jan, Reichetzeder Christoph, Kalk Philipp, Pfab Thiemo, Tsuprykov Oleg, Winter Stefan, Hofmann Ute, Li Jian, Püschel Gerhard P, Lang Florian, Schuppan Detlef, Schwab Matthias, Schaeffeler Elke

Abstract excerpt

Maternal environmental factors can impact on the phenotype of the offspring via the induction of epigenetic adaptive mechanisms. The advanced fetal programming hypothesis proposes that maternal genetic variants may influence the offspring's phenotype indirectly via epigenetic modification, despite the absence of a primary genetic defect. To test this hypothesis, heterozygous female eNOS knockout mice and wild...

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Identifiers

PMID: 27175980
DOI: 10.1080/15592294.2016.1184800
PMCID: PMC4939931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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