Article
rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1.
Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2015
Saeki Norihisa, Ono Hiroe, Yanagihara Kazuyoshi, Aoyagi Kazuhiko, Sasaki Hiroki, Sakamoto Hiromi, Yoshida Teruhiko
Abstract excerpt
Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene. The protein product of this gene inhibits cell growth, and the T allele significantly suppresses the transcriptional activity of the -3.2 kb PSCA upstream region....
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