Comparison of Diffusion MRI Acquisition Protocols for the In Vivo Characterization of the Mouse Spinal Cord: Variability Analysis and Application to an Amyotrophic Lateral Sclerosis Model.

doi:10.1371/journal.pone.0161646

Article

Comparison of Diffusion MRI Acquisition Protocols for the In Vivo Characterization of the Mouse Spinal Cord: Variability Analysis and Application to an Amyotrophic Lateral Sclerosis Model.

PloS one - 1 Jan 2016

Figini Matteo, Scotti Alessandro, Marcuzzo Stefania, Bonanno Silvia, Padelli Francesco, Moreno-Manzano Victoria, García-Verdugo José Manuel, Bernasconi Pia, Mantegazza Renato, Bruzzone Maria Grazia, Zucca Ileana

Abstract excerpt

Diffusion-weighted Magnetic Resonance Imaging (dMRI) has relevant applications in the microstructural characterization of the spinal cord, especially in neurodegenerative diseases. Animal models have a pivotal role in the study of such diseases; however, in vivo spinal dMRI of small animals entails additional challenges that require a systematical investigation of acquisition parameters. The purpose of this study...

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Comparison of Diffusion MRI Acquisition Protocols for the In Vivo Characterization of the Mouse Spinal Cord: Variability Analysis and Application to an Amyotrophic Lateral Sclerosis Model.

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