Article
Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells.
Oncotarget - 4 Oct 2016
Bhat Jaydeep, Sosna Justyna, Fritsch Jürgen, Quabius Elgar Susanne, Schütze Stefan, Zeissig Sebastian, Ammerpohl Ole, Adam Dieter, Kabelitz Dieter
Abstract excerpt
Previously, the expression of a non-secreted IL-4 variant (IL-4δ13) has been described in association with apoptosis and age-dependent Th2 T-cell polarization. Signaling pathways involved in this process have so far not been studied. Here we report the induction of IL-4δ13 expression in human γδ T-cells upon treatment with a sublethal dose of histone deacetylase (HDACi) inhibitor valproic acid (VPA). Induction of...
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