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Article

Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes.

American journal of physiology. Heart and circulatory physiology - 15 Jun 2013

Gang Hongying, Shaw James, Dhingra Rimpy, Davie James R, Kirshenbaum Lorrie A

Abstract excerpt

Gene transcription is regulated by post-translation modifications. Histone deacetylases (HDACs) remove acetyl groups from histone and non-histone factors inhibiting transcription. Proinflammatory cytokines such as TNFα activate the canonical nuclear factor-κB (NF-κB) pathway. Earlier we established a cytoprotective role for NF-κB in the heart. Though a causal relationship for HDAC1 and NF-κB has been established,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23585133
DOI: 10.1152/ajpheart.00093.2013

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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