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Cytotoxic and targeted therapy for hereditary cancers

20 Jul 2016

Abstract excerpt

There is a number of drugs demonstrating specific activity towards hereditary cancers. For example, tumors in BRCA1/2 mutation carriers usually arise via somatic inactivation of the remaining BRCA allele, which makes them particularly sensitive to platinum-based drugs, PARP inhibitors (PARPi), mitomycin C, liposomal doxorubicin, etc. There are several molecular assays for BRCA-ness, which permit to reveal...

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PMID: 27555886
DOI: 10.1186/s13053-016-0057-2

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