Drug therapy for hereditary cancers

doi:10.1186/1897-4287-9-5

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Drug therapy for hereditary cancers

6 Aug 2011

Abstract excerpt

Tumors arising in patients with hereditary cancer syndromes may have distinct drug sensitivity as compared to their sporadic counterparts. Breast and ovarian neoplasms from BRCA1 or BRCA2 mutation carriers are characterized by deficient homologous recombination (HR) of DNA, that makes them particularly sensitive to platinum compounds or inhibitors of poly (ADP-ribose) polymerase (PARP). Outstandingly durable...

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PMID: 21819606
DOI: 10.1186/1897-4287-9-5

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