Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21

24 Aug 2016

Abstract excerpt

TGF-β1, upregulated in keloid tissue, promotes the proliferation, collagen formation and differentiation of dermal fibroblasts. miR-21 is one of microRNAs first found in human genome. The aim of our study is to explore the mechanisms of miR-21 in TGF-β1-induced scar fibroblasts proliferation and transdifferentiation. In the present study, first we found that TGF-β1 promoted scar fibroblasts proliferation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective Tissue Growth Factor Research
Share to Dermatologic Treatments and Research
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27554193
DOI: 10.1038/srep32231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21PMID 27554193Read ↗

MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling PathwaySemantic proximity Read ↗

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.Semantic proximity Read ↗

TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signalingSemantic proximity Read ↗

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar FibroblastsSemantic proximity Read ↗

Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexitiesSemantic proximity Read ↗

Microrna-21: A Central Regulator of Fibrotic Diseases Via Various TargetsSemantic proximity Read ↗

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.Semantic proximity Read ↗

TGF-β signaling in health and diseaseSemantic proximity Read ↗

The Research Progress in Transforming Growth Factor-β2Semantic proximity Read ↗

Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathwaySemantic proximity Read ↗

Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesisSemantic proximity Read ↗

Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancementsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.