Article
Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5.
Scientific reports - 23 Aug 2016
Feng Xiaoke, Shi Yumeng, Xu Lingxiao, Peng Qiuyue, Wang Fang, Wang Xiaoxi, Sun Wei, Lu Yan, Tsao Betty P, Zhang Miaojia, Tan Wenfeng
Abstract excerpt
Receptor activator of nuclear factor κB ligand (RANKL) is critically involved in bone erosion of rheumatoid arthritis (RA). We previously reported association between younger age at onset of RA and a RANKL promoter SNP that conferred an elevated promoter activity via binding to a transcription factor SOX5. Here we study the regulation of SOX5 levels in relation to RANKL expression in RA synovial fibroblasts (SF)...
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