Article
The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.
Developmental cell - 1 Aug 2001
Smits P, Li P, Mandel J, Zhang Z, Deng J M, Behringer R R, de Crombrugghe B, Lefebvre V
Abstract excerpt
L-Sox5 and Sox6 are highly identical Sry-related transcription factors coexpressed in cartilage. Whereas Sox5 and Sox6 single null mice are born with mild skeletal abnormalities, Sox5; Sox6 double null fetuses die with a severe, generalized chondrodysplasia. In these double mutants, chondroblasts poorly differentiate. They express the genes for all essential cartilage extracellular matrix components at low or...
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