Article
Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma.
Scientific reports - 23 Aug 2016
Zhu Hui, Lv Zheng, An Changming, Shi Meng, Pan Wenting, Zhou Liqing, Yang Wenjun, Yang Ming
Abstract excerpt
The role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) and its functional single nucleotide polymorphisms (SNPs) in papillary thyroid carcinoma (PTC) is still largely unclear. Therefore, we investigated the involvement of lncRNA HOTAIR and its three haplotype-tagging SNPs (htSNPs) in PTC. There was higher expression of HOTAIR in PTC tissues compared to normal tissues. A series of gain-loss...
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